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October 24, 2024Cardiology in Review

A Concise Review of Marfan Syndrome with a Congenital Cardiac Surgery Focus

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Key result

Aortic and mitral surgeries remain critical for survival against life-threatening cardiovascular complications in Marfan syndrome.

Why the study?

Cardiovascular complications in Marfan syndrome are life-threatening, making intensive care and tailored surgical management critical to patient survival.

Population

Patients with Marfan syndrome

Design

Review

Authors

AVAndrew D. VogelUniversity of North Carolina at Chapel HillGGG. GalánVall d'Hebron Institut de RecercaTRTaufiek Konrad RajabPediatric / Congenital Cardiology

Discussion

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Implication

Supports surgical thresholds in Marfan syndrome; leaves open prospective validation of timing and techniques.

Structured PICO

P
Population
Patients with Marfan syndrome
I
Intervention
Surgical management (including aortic root surgery, valve-sparing root replacements, aortic root replacements with conduits, and mitral valve repairs), medical, and intensive care management

This review outlines the diagnosis, complications, and surgical management strategies for cardiovascular pathologies in patients with Marfan syndrome.

Cite This Study

Vogel et al. (2024) conducted a review in Marfan syndrome. Surgical management was evaluated. Surgical management of Marfan syndrome, including aortic root surgery and mitral valve repairs, is critical for survival due to life-threatening cardiovascular complications.

synapsesocial.com/papers/6a14f57e2f0e848eb39aeeachttps://doi.org/10.1097/crd.0000000000000619

Topics

Congenital heart disease adults
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Manifestations of Marfan Syndrome in Infancy and Childhood1973 · 115 citations
  2. 2The revised Ghent nosology for the Marfan syndrome: Table 12010 · 2,258 citations
  3. 3Progression of Aortic Dilatation and the Benefit of Long-Term β-Adrenergic Blockade in Marfan's Syndrome1994 · 1,076 citations
  4. 4Novel exon skipping mutation in the fibrillin‐1 gene: Two ‘hot spots’ for the neonatal Marfan syndrome1999 · 103 citations
  5. 5Transcatheter versus surgical aortic valve replacement in severe, symptomatic aortic stenosis.2018 · 37 citations