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May 12, 1994New England Journal of Medicine

Progression of Aortic Dilatation and the Benefit of Long-Term β-Adrenergic Blockade in Marfan's Syndrome

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Why the study?

Does long-term prophylactic beta-adrenergic blockade reduce the rate of aortic dilatation and development of aortic complications in patients with Marfan's syndrome?

Population

Patients with Marfan's syndrome

Follow-up

Long-term

Authors

JSJennifer L. ShoresMemorial HospitalKBKenneth R. BergerJohns Hopkins UniversityEMEdmond A. MurphyEnvironmental Protection Agency

Discussion

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Implication

May support beta-blockade in Marfan aortopathy; leaves open confirmation by randomized trials.

Key Points

  • To evaluate the efficacy of prophylactic beta-adrenergic blockade in reducing aortic enlargement and preventing complications in Marfan syndrome.
  • Administered prophylactic beta-adrenergic blockade in patients diagnosed with Marfan's syndrome.
  • Monitored the rate of aortic dilatation and tracked cardiovascular complications over long-term follow-up.
  • Beta-adrenergic blockade significantly slowed the rate of progressive aortic dilatation.
  • Prophylactic treatment reduced the incidence of severe aortic complications in a subset of patients.

Structured PICO

Does long-term prophylactic beta-adrenergic blockade reduce the rate of aortic dilatation and development of aortic complications in patients with Marfan's syndrome?

P
Population
Patients with Marfan's syndrome
I
Intervention
Long-term prophylactic beta-adrenergic blockade
O
Outcome
Rate of aortic dilatation and development of aortic complications

Long-term beta-blockade is beneficial for slowing aortic dilatation and preventing complications in Marfan's syndrome.

Cite This Study

Shores et al. (1994) studied this question.

synapsesocial.com/papers/69dadc490d8d6ef495a3c6ddhttps://doi.org/10.1056/nejm199405123301902

Topics

Heart failureHFrEF treatment
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Also Consider

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