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May 1, 1988Archives of Surgery

Effect of β-Adrenergic Blockade on the Growth Rate of Abdominal Aortic Aneurysms

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Why the study?

Does long-term beta-blockade reduce the growth rate of abdominal aortic aneurysms in outpatients with AAA > 3 cm?

Population

27 outpatients with abdominal aortic aneurysms larger than 3 cm, with at least two serial ultrasound size…

Comparison

Long-term beta-blockade vs No beta-blockade

Design

Cohort

Follow-up

mean, 34 months

Authors

SLSteven D. LeachDartmouth College

Discussion

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Implication

May slow AAA growth with beta-blockers; hypothesis-generating, requiring RCTs before practice change.

Structured PICO

Does long-term beta-blockade reduce the growth rate of abdominal aortic aneurysms in outpatients with AAA > 3 cm?

P
Population
27 outpatients with abdominal aortic aneurysms (AAA) larger than 3 cm, with at least two serial ultrasound size determinations over a minimum six-month interval and a documented medication history.
I
Intervention
Long-term beta-blockade
C
Comparator
No beta-blockade
O
Outcome
Growth rate of abdominal aortic aneurysms (cm/y)surrogate

Long-term beta-blockade is associated with a significantly decreased growth rate of abdominal aortic aneurysms, suggesting a potential pharmacological strategy to delay disease progression.

Limitations

  • small sample size
  • retrospective study

Cite This Study

Steven D. Leach (1988) studied this question.

synapsesocial.com/papers/6a14f5802f0e848eb39aeebahttps://doi.org/10.1001/archsurg.1988.01400290092015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contribution of Abdominal Aortic Aneurysmectomy to Prolongation of Life1966 · 518 citations
  2. 2Abdominal Aortic Aneurysm in High-risk Patients1984 · 174 citations
  3. 3Growth rate of abdominal aortic aneurysms as measured by computed tomography1985 · 97 citations
  4. 4Is 80 Years Too Old For Aneurysmectomy?1976 · 132 citations
  5. 5Clinical Fate of the Patient With Asymptomatic Abdominal Aortic Aneurysm and Unfit for Surgical Treatment1972 · 277 citations