Key result
Visceral obesity was significantly associated with diastolic dysfunction, with 40% of this negative effect explained by increased myocardial triglycerides, 39% by reduced PCr/ATP, and 21% by LV concentric remodeling.
Population
80 adult subjects from the Oxfordshire population across a wide range of body mass indices with no…
Design
Cross-sectional, Analysis was blinded to descriptive data
Authors
Loading...
Supports metabolic targets in obesity-related HFpEF; hypothesis-generating without causal or outcome data.
Cross-Sectional (n=80)
No
Effect estimate: r = -0.46
p-value: p=0.001
Myocardial energetics and steatosis are more important in determining LV diastolic function than concentric hypertrophy in obesity, highlighting metabolic targets for HFpEF.
Rayner et al. (2017) conducted a cross-sectional in Obesity (n=80). Visceral obesity (Observational) was evaluated on Peak diastolic strain rate (r = -0.46, p=0.001). Visceral obesity was significantly associated with diastolic dysfunction, with 40% of this negative effect explained by increased myocardial triglycerides, 39% by reduced PCr/ATP, and 21% by LV concentric remodeling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: