What is the clinical evidence from this study?

Population: end-stage renal disease. Intervention: thromboelastography.

What does this research mean for the field?

Patients with end-stage renal disease exhibit a significantly higher prevalence of abnormal haemostatic profiles, particularly hypocoagulability, compared to patients with coronary artery disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to evaluate the haemostatic profiles of patients with end-stage renal disease (ESRD) using thromboelastography (TEG).

January 1, 2011Thrombosis and Haemostasis

Haemostatic profiles assessed by thromboelastography in patients with end-stage renal disease

View Full Paper

Ask AI

Bookmark

Key result

The provided text contains only journal editorial board information and no clinical study data.

Why the study?

Does thromboelastography reveal different haemostatic profiles in patients with end-stage renal disease on haemodialysis compared to patients with coronary artery disease?

Population

140 subjects, comprising 70 patients with end-stage renal disease on haemodialysis and a control group of 70…

Comparison

Thromboelastography assessment of whole blood… vs Control group of subjects with coronary artery…

Design

Case-control

Authors

ADAndrew DarlingtonPiedmont HealthCare JFJosé Luis FerreiroInterventional Cardiology MUMasafumi UenoKeio University

Discussion

Member takes

Implication

Abnormal TEG profiles in ESRD on HD may signal hypocoagulability; case-control data leaves open utility for guiding antithrombotic decisions versus CAD.

Key Points

This study aims to evaluate the haemostatic profiles of patients with end-stage renal disease (ESRD) using thromboelastography (TEG).
Analyzed whole blood samples from 70 ESRD patients and 70 controls using TEG.
Constructed profiles based on maximum amplitude (MA) and reaction time (R) values.
Compared coagulation and aggregation parameters between ESRD patients and the control group.
R values significantly higher in ESRD patients (8.2 ± 2.8 min) compared to controls (5.7 ± 1.9 min, p<0.0001).
31% of ESRD patients had normal coagulation parameters versus 56% of controls (p=0.006).
42.9% of ESRD patients exhibited a hypocoagulable status compared to 8.9% in the control group (p<0.0001).

Structured PICO

Does thromboelastography reveal different haemostatic profiles in patients with end-stage renal disease on haemodialysis compared to patients with coronary artery disease?

Population

140 subjects, comprising 70 patients with end-stage renal disease (ESRD) on haemodialysis and a control group of 70 subjects with coronary artery disease.

Intervention

Thromboelastography (TEG) assessment of whole blood samples

Comparator

Control group of subjects with coronary artery disease

Outcome

Distribution of enzymatic and cellular abnormalities assessed by thromboelastography, specifically maximum amplitude (MA) and reaction time (R)surrogate

Patients with end-stage renal disease on haemodialysis exhibit a high prevalence of abnormal haemostatic profiles on thromboelastography, primarily driven by delayed thrombin generation (hypocoagulability) rather than altered platelet function.

Cite This Study

Darlington et al. (2011) studied end-stage renal disease. thromboelastography was evaluated. The provided text contains only journal editorial board information and no clinical study data.

synapsesocial.com/papers/6a152cb0cb801b7f954e2add https://doi.org/10.1160/th10-12-0785

Topics

Coronary artery disease

View Full Paper

Ask AI

Bookmark

Implication

Abnormal TEG profiles in ESRD on HD may signal hypocoagulability; case-control data leaves open utility for guiding antithrombotic decisions versus CAD.

Haemostatic profiles assessed by thromboelastography in patients with end-stage renal disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Haemostatic profiles assessed by thromboelastography in patients with end-stage renal disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider