Key result
Voltage-gated sodium channel mutations underlie a spectrum of inherited channelopathies, including Brugada syndrome, long QT syndrome, and inherited conduction disorders.
Design
Review
Authors
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Supports genetic evaluation in suspected channelopathies; leaves open mutation-specific therapeutic development.
This review provides a comprehensive overview of voltage-gated sodium channels, their mutations in cardiac channelopathies, and their pharmacological targets.
Andavan et al. (2011) conducted a review in Channelopathies (e.g., Brugada syndrome, long QT syndrome). Voltage-gated sodium channel mutations underlie a spectrum of inherited channelopathies, including Brugada syndrome, long QT syndrome, and inherited conduction disorders.
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