Key result
Current commercial BNP and NT-proBNP assays cross-react with proBNP to a varying extent, highlighting the need for better characterization of circulating forms to improve assay standardization.
Better characterization of circulating BNP forms is necessary to define standards for assay standardization and improve diagnostic sensitivity in heart failure.
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May warrant cautious BNP/NT-proBNP interpretation in HF; leaves open standardization via proBNP form characterization.
Johannes Mair (2008) conducted a review in Heart failure. Current commercial BNP and NT-proBNP assays cross-react with proBNP to a varying extent, highlighting the need for better characterization of circulating forms to improve assay standardization.
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