Key result
Computer simulations of 3D human atria models demonstrated that spatially altering atrial wall thickness causes spiral wave drift from thicker to thinner regions and along ridge-like structures.
Spatially altering atrial wall thickness and pectinate muscle bridges significantly influence the drift and anchoring of spiral waves, providing mechanistic insights into atrial fibrillation dynamics.
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Simulations link atrial wall thickness to spiral wave drift; hypothesis-generating for AF mechanisms and requires in vivo validation.
Kharche et al. (2015) studied Spiral wave dynamics in the human atrium. Anatomical structures (wedge, ridge, bridge geometries) was evaluated on Spiral wave drift quantified by tip trajectory. Computer simulations of 3D human atria models demonstrated that spatially altering atrial wall thickness causes spiral wave drift from thicker to thinner regions and along ridge-like structures.
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