Why the study?
Does a low-amplitude shock applied over a coarse mesh of lines achieve defibrillation in a model of ventricular fibrillation?
Does a low-amplitude shock applied over a coarse mesh of lines achieve defibrillation in a model of ventricular fibrillation?
Proposes a novel, theoretical low-energy defibrillation method using a coarse mesh of lines in a ventricular fibrillation model.
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Hypothesis-generating for low-energy defibrillation; requires validation before any clinical translation.
Ventricular fibrillation, the major reason behind sudden cardiac death, is turbulent cardiac electrical activity in which rapid, irregular disturbances in the spatiotemporal electrical activation of the heart make it incapable of any concerted pumping action. Methods of controlling ventricular fibrillation include electrical defibrillation as well as injected medication. Electrical defibrillation, though widely used, involves subjecting the whole heart to massive, and often counterproductive, electrical shocks. We propose a defibrillation method that uses a very low-amplitude shock (of order mV) applied for a brief duration (of order 100 ms) and over a coarse mesh of lines on our model ventricle.
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Sinha et al. (2001) studied this question.
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