Key result
Alternans of action potential duration and rate maladaptation appear mechanistically involved in the initiation, development, and persistence of atrial fibrillation.
This review highlights that action potential duration alternans and rate maladaptation are mechanistically involved in the initiation and persistence of atrial fibrillation.
Should not change AF management; leaves open whether targeting APD alternans improves outcomes.
This review highlights the role of atrial monophasic action potential duration (APD) in understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way appear mechanistically involved in AF initiation, development, and persistence. The underlying pathophysiology warrants further investigation.
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Franz et al. (2012) conducted a review in Atrial fibrillation. Alternans of action potential duration and rate maladaptation appear mechanistically involved in the initiation, development, and persistence of atrial fibrillation.
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