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May 31, 2025Scientific ReportsOpen Access

A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization

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Authors

YSYusuke SudoRKRio KamashitaTTTsunehiko Takamura

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Overview

Multicenter cross-sectional study reveals altered insular functional connectivity in females with anorexia nervosa, suggesting neural circuits driving negative emotional bias and taste aversion.

Key Points

  • To identify alterations in resting-state functional connectivity between functionally localized insular subregions and the whole brain in patients with anorexia nervosa.
  • Conducted a multicenter cross-sectional reanalysis of resting-state fMRI data from 114 female patients with anorexia nervosa and 135 female healthy controls.
  • Parcellated the bilateral insula into 12 functional seed regions of interest (6 per hemisphere) and calculated functional connectivity across 142 whole-brain target regions.
  • Patients with anorexia nervosa demonstrated significantly increased resting-state functional connectivity between the dorsal anterior insula and the amygdala compared to healthy controls (analysis-level FDR-corrected p < 0.05).
  • Patients exhibited significantly decreased resting-state functional connectivity between the posterior division of the dorsal middle insula and the opercular cortex (analysis-level FDR-corrected p < 0.05).

Cite This Study

Sudo et al. (2025) studied this question.

synapsesocial.com/papers/6a1532995347fbb1739f63cchttps://doi.org/10.1038/s41598-025-03641-0
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