Key result
The authors proposed 4-D BioChemInfoPhysics models using momentum transfer equations to explain the automation, transportation, propagation, and orientation of cardiac cellular and sub-cellular vibrations.
A theoretical 4-D BioChemInfoPhysics model suggests that cardiac cells and subcellular components function as biological liquid plasma resonators.
Theoretical cardiac vibration models offer no clinical guidance; leaves open experimental validation of BioChemInfoPhysics resonators in vivo.
Problem statement: Cardiovascular Diseases (CVD) continued to the leading cause of death. Failure or abnormal cardiac cellular or sub-cellular (oscillations) could lead failure or abnormal heart beats that could CVD. Understanding the mechanisms of the vibrations (oscillations) could to prevent or to treat the diseases. Scientists have studied the mechanisms more than 100 years. To our knowledge, the mechanisms are still unclear today. this investigation, based on published data or results, conservation laws of momentum as well as the energy, in views of biology, biochemistry, informatics physics (BioChemInfoPhysics), we proposed our models of cardiac cellular and -cellular vibrations (oscillations) of biological components, such as free in Biological Fluids (BF), Biological Membranes (BM), Ca++H+ (Ca++ and Na+K+) , Na+Ca++ exchangers (NCX), Ca++ carriers and myosin heads. Approach: models were described with 4-D (x, y, z, t or r, θ, z, t) momentum equations in mathematical physics. Results: The momentum equations were solved with free and forced, damped, un-damped and over-damped, (oscillations). The biological components could be modeled as resonators vibrators (oscillators), such as liquid plasmas, membranes, active springs, springs and active swings. Conclusion: We systematically new insights of automation (ignition and maintain), transportation, propagation orientation of the cardiac cellular and sub-cellular vibrations (oscillations) resonances, with our BioChemInfoPhysics models of 4-D momentum transfer equations. modeling results implied: Auto-rhythmic cells (Sinoatrial Node Cells (SANC), Node Cells (AVNC), Purkinje fibers), non-Auto-rhythmic ventricular and their Sarcoplasmic Reticulums (SR) work as Biological Liquid Plasma (BLPR). The resonators were biological clocks and mainly made of BF, and BM Transporters (BMT) that had mutually adapted and produced Biological Plasma Resonance Frequencies (BLPRF) for the resonators during their natural . The resonators naturally vibrate (oscillate) near the SANC SR BLPRF had the highest BLPRF among them.
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Cheng et al. (2009) studied Cardiovascular Diseases. BioChemInfoPhysics Models was evaluated. The authors proposed 4-D BioChemInfoPhysics models using momentum transfer equations to explain the automation, transportation, propagation, and orientation of cardiac cellular and sub-cellular vibrations.
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