Key result
Lifelong nondaily smoking linked to ~82% higher all-cause mortality versus never smoking.
Why the study?
The effect of reducing smoking from daily to nondaily smoking and the dose-response relationship at low smoking levels were poorly understood.
Does low-intensity and nondaily smoking increase mortality risk compared to never smoking in adults?
Cohort (n=505,500)
Does low-intensity and nondaily smoking increase mortality risk compared to never smoking in adults?
Effect estimate: HR 1.82 (95% CI 1.65-2.01)
Even low-intensity, nondaily smoking (6-10 cigarettes per month) is associated with significantly higher mortality risk compared to never smoking, emphasizing that all smokers should quit completely.
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Alerts clinicians to nondaily smoking risks; extends observational data but leaves practice change open pending trials.
Inoue‐Choi et al. (2020) conducted a cohort in Smoking (n=505,500). Nondaily and daily cigarette smoking vs. Never smoking was evaluated on All-cause mortality (HR 1.82, 95% CI 1.65-2.01). Lifelong nondaily smoking was associated with higher all-cause mortality than never smoking (HR 1.82; 95% CI 1.65-2.01), as was daily smoking (HR 2.32; 95% CI 2.25-2.38).
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