Key result
Obstructive CAD is linked to ~48% higher plasma Cyclophilin A levels versus non-obstructive disease.
Why the study?
Very few studies have examined the association of plasma CyPA with coronary artery disease in India, prompting this evaluation of its relationship with CAD severity.
Does plasma cyclophilin A level correlate with the severity of coronary artery disease in symptomatic patients?
Cross-Sectional (n=100)
No
Does plasma cyclophilin A level correlate with the severity of coronary artery disease in symptomatic patients?
Absolute Event Rate: 66.6% vs 44.9%
p-value: p=0.0001
Plasma cyclophilin A levels are significantly elevated in patients with obstructive coronary artery disease and correlate positively with hs-CRP, suggesting its potential as a biomarker for CAD severity.
Does not support clinical adoption of cyclophilin A testing; leaves open its role as a CAD severity biomarker.
Background: Plasma cyclophilin A (CyPA), an emerging biomarker of cardiovascular disease, is likely to play a crucial role in all stages of atherosclerosis. Very few studies have been conducted on the association of plasma CyPA with coronary artery disease (CAD) in India. The aim of the present study was to determine an association between plasma CyPA levels and CAD severity. Methods: The present cross-sectional observational study was conducted on 100 patients aged ≥18 years who presented with symptoms suggestive of CAD. The presence or absence of cardiovascular risk factors such as gender, hypertension, diabetes mellitus, dyslipidaemia, family H/O CAD, smoking, etc. were noted. Coronary angiography was performed on each patient. Quantitative estimation of plasma CypA levels and high-sensitivity C-reactive protein (hs-CRP) was done. Results: The mean serum CypA (66.6 Vs 44.9 ng/ml) and hs-CRP (29.8 Vs 21.4 mg/l) were significantly higher in patients with obstructive CAD as compared to non-obstructive CAD. There was a statistically significant positive correlation (r=0.251) between CypA levels and hs-CRP (p value=0.012). The mean low-density lipoprotein cholesterol (181 Vs 160.8 mg/dL) and mean triglycerides (179 Vs 168 mg/dl) were significantly higher in patients with obstructive CAD as compared to non-obstructive CAD. There was no statistically significant difference between the type of CAD and mean total cholesterol and high-density lipoprotein cholesterol. Conclusions: CypA levels were increased in obstructive CAD patients. High CypA serum levels could be a novel biomarker in CAD patients associated with severe CAD.
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Parhad et al. (2025) conducted a cross-sectional in Coronary artery disease (n=100). Obstructive CAD vs. Non-obstructive CAD was evaluated on Mean plasma Cyclophilin A levels (ng/ml) (p=0.0001). Mean plasma Cyclophilin A levels were significantly higher in patients with obstructive coronary artery disease compared to those with non-obstructive disease (66.6 vs 44.9 ng/ml, p=0.0001).
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