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May 26, 2026Oxford Medical Case Reports0 citationsOpen Access

SOD1 amyotrophic lateral sclerosis associated with Neurosarcoidosis: a case report and review of the literature

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AAAl-alya AlsabahHRHaatem Reda

Key Points

  • To present a case of coexisting SOD1 ALS and neurosarcoidosis and discuss associated challenges and treatment outcomes.
  • Described case of a 37-year-old man.
  • Reviewed diagnostic timeline and therapeutic interventions over five years.
  • Discussed relevant literature on ALS and neurosarcoidosis.
  • Significant challenges in diagnosing and treating coexisting conditions.
  • Outcomes evaluated over five years of care showed variable responses to treatment.
  • Literature review highlighted the rarity and complexity of dual diagnosis.

Abstract

Abstract We describe a 37-year-old man with coexisting amyotrophic lateral sclerosis (ALS) caused by a mutation in superoxide dismutase 1 (SOD1) and probable neurosarcoid myeloradiculitis. The concurrence of the two rare conditions posed significant diagnostic and therapeutic challenges. We discuss the diagnostic timeline, therapeutic interventions, outcomes over half a decade of care, and a review of relevant literature.

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Cite This Study

Alsabah et al. (2026) studied this question.

synapsesocial.com/papers/6a153a2eb5d9c58d83e8cf17https://doi.org/10.1093/omcr/omag078
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