From "Heterologous Calling" to "Endogenous Activation": The Four-Stage Evolution of Gene-Editing Technologies and the Self-Consistent Ethical Framework —— A Unified Theory Based on the Four Fundamental Laws of YuanXian Theory

Gene-editing technology is currently undergoing a fundamental, paradigm-shifting transition from an "exogenous mechanical tool" to an "endogenous programmatic subroutine." Grounded in the Four Fundamental Laws of YuanXian Theory (YXT), this research treatise introduces the deterministic Four-Stage Evolution Model of genome manipulation. The technological arc traces a clear reduction in the system's heterogeneity index: Stage I (Canonical Cas9) represents invasive heterologous disruption; Stage II (Base Editing) acts as refined local chemical tailoring; Stage III (Prime Editing) emulates native replication and proofreading; and Stage IV (Endogenous Activation) marks the milestone where the Cosmic Living Organism Psi directly deploys its own native enzymatic machinery. Through rigorous ontological and biophysical framing, we demonstrate that all prevailing structural pathologies in current CRISPR applications—including off-target cleavage cascades, rigid PAM sequence restrictions, deficient Homology-Directed Repair (HDR) efficiencies, and systemic host immunogenicity—share a singular root cause: Heterogeneity, defined as the fundamental impedance mismatch between an alien prokaryotic endonuclease and the complex eukaryotic host environment. Stage IV completely eliminates exogenous viral or bacterial protein mass, relying exclusively on informational nucleic acid signals to recruit native human repair complexes, thereby radically dissolving these technical bottlenecks. Building upon this technological blueprint, we mathematically derive the "Self-Consistent Editing" Ethical Framework. This operational model establishes three unalterable imperatives corresponding to the cosmic constitutional baseline: Precedence of Global Self-Consistency (derived from Law IV), Transparency of Informational Conservation (derived from Law I), and Non-Branching Historical Accountability (derived from Law II). This framework provides deterministic, actionable boundary criteria for controversial frontiers such as germline modifications and genetic enhancements. Furthermore, all core propositions, heterogeneity metrics, and prediction rules developed in this treatise have been fully formalized and co-verified via the Lean 4 and Rocq twin automated proof engines, ensuring an absolute zero-defect logical structure. The complete open-source formal standard library is permanently deployed and maintained at YXT-Formalization. 基因编辑技术正经历从“外源性机械工具”向“内源性程序子例程”的根本性范式转变。本文基于元宪理论(YXT)的四大基本规律,系统性地提出了基因编辑技术的“四阶段演进模型”。该技术弧线清晰地映射了系统异源性指数的逐阶递减:第一阶段(传统 Cas9)