Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection
Key result
Hospitalization for rhinovirus infection was associated with higher 1-year mortality than influenza (p<0.01), with ICU admission being a major risk factor (OR 9.56; 95% CI 2.17-42.18).
Why the study?
Does rhinovirus infection increase mortality compared to influenza infection in hospitalized adult patients?
Population
1,946 adult patients hospitalized for pneumonia caused by rhinovirus or influenza infection in a single…
Comparison
Rhinovirus infection vs Influenza infection
Design
Cohort
Follow-up
at least 3 months up to 15 months
Authors
Discussion
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Member takes
Implication
May warrant heightened vigilance in rhinovirus hospitalizations; leaves open whether targeted strategies improve outcomes versus influenza.
Study Design
Type
Cohort (n=1,946)
Multicenter
No
Structured PICO
Does rhinovirus infection increase mortality compared to influenza infection in hospitalized adult patients?
P
Population
1,946 adult patients hospitalized for pneumonia caused by rhinovirus (n=728) or influenza infection (n=1,218) in a single teaching hospital center over a one-year period.
I
Intervention
Rhinovirus infection
C
Comparator
Influenza infection
O
Outcome
Mortality (30-day, 90-day, and 1-year)hard clinical
Main Result
p-value: p=<0.01
Rhinovirus infection in hospitalized adults is associated with significantly higher mortality and longer hospitalization compared with influenza virus infection, particularly in institutionalized older adults.
Cite This Study
Hung et al. (2017) conducted a cohort in Pneumonia caused by rhinovirus or influenza infection (n=1,946). Rhinovirus infection vs. Influenza infection was evaluated on 1-year mortality (p=<0.01). Hospitalization for rhinovirus infection was associated with higher 1-year mortality than influenza (p<0.01), with ICU admission being a major risk factor (OR 9.56; 95% CI 2.17-42.18).