Key result
High traditional risk factor burden linked to an ~8% coronary stenosis progression rate.
Why the study?
The long-term course of coronary atherosclerosis had not been studied in large nationwide cohorts to help identify patients at risk for future coronary events.
Cohort (n=248,736)
Yes
Absolute Event Rate: 8.1% vs 0.6%
Coronary atherosclerosis progresses slowly overall, but the risk of progression is highly dependent on the presence of traditional risk factors, with the relative impact being greatest in younger patients and women.
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Multiple risk factors accelerate progression most in younger patients and women; extends prior associations but leaves open intervention effects.
Mohammad et al. (2022) conducted a cohort in Coronary atherosclerosis (n=248,736). ≥4 traditional risk factors vs. No baseline risk factors was evaluated on Stenosis progression rate. Traditional risk factors accelerated coronary atherosclerosis, increasing the stenosis progression rate from 0.6% in patients with no risk factors to 8.1% in those with ≥4 risk factors.
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