Key result
Statins reduce urinary albumin and protein excretion in CKD without altering eGFR.
Why the study?
Although statins improve lipid profiles, it remains controversial whether statins can improve renal function in patients with chronic kidney disease.
Does statin use improve renal function in patients with chronic kidney disease?
Meta-Analysis (n=37,391)
Does statin use improve renal function in patients with chronic kidney disease?
Effect estimate: WMD -2.04 (95% CI -3.53 to -0.56)
p-value: p=.007
Statin use in patients with chronic kidney disease may slow disease progression by lowering urinary albumin and protein excretions and increasing creatinine clearance, though it does not significantly affect eGFR.
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Statin use may reduce albuminuria in CKD without eGFR benefit; extends surrogate evidence while leaving hard renal outcomes open.
Zhao et al. (2021) conducted a meta-analysis in chronic kidney disease (n=37,391). statins vs. control was evaluated on urinary albumin excretions (WMD -2.04, 95% CI -3.53 to -0.56, p=.007). Statin use in patients with chronic kidney disease significantly reduced urinary albumin (WMD -2.04; 95% CI -3.53 to -0.56; p=0.007) and protein excretions, but did not significantly change eGFR.
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