What is the clinical evidence from this study?

Population: Normal aortic valve function. Intervention: 3D-printed aortic valve phantom and 4D Flow MRI. Primary outcome: Net flow proximal and distal to the valve.

What does this research mean for the field?

A 3D-printed aortic valve phantom can successfully replicate physiological function and complex flow patterns, which can be accurately evaluated using cine- and 4D Flow MRI. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 3, 20203D Printing in MedicineOpen Access

Simulation of semilunar valve function: computer-aided design, 3D printing and flow assessment with MR

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Key result

A 3D-printed aortic valve phantom demonstrated physiological function, with 4D Flow MRI showing consistent net flow proximal (26.03 mL/s) and distal (26.09 mL/s) to the valve.

Why the study?

An enhanced understanding of semilunar valve structural characteristics is fundamental to evaluating pathology and developing prosthetic or bioprosthetic valves.

Population

3D-printed phantom of a normal tricuspid aortic valve modeled from previously published geometric data

Design

In vitro proof of concept simulation study

Authors

NHNabil HusseinUniversity of Alberta PVPascal Voyer-NguyenUniversity of Toronto SPSharon PortnoyGreat Ormond Street Hospital

Discussion

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Implication

Supports feasibility of 3D-printed valve phantoms for hemodynamic testing; leaves open clinical translation pending validation studies.

Structured PICO

Population

3D-printed phantom of a 'normal' tricuspid aortic valve modeled from previously published geometric data

Intervention

Flow assessment using an MRI compatible flow pump (peak flow 100 mL/s, 60 bpm) and 4D flow MRI

Outcome

Valve motion, flow velocity, and complex flow patterns assessed by cine imaging, 2D and 4D phase-contrast MRIsurrogate

This proof-of-concept study demonstrates the feasibility of combining computer-aided design, 3D printing, and 4D flow MRI to evaluate the structural and hemodynamic characteristics of aortic valve phantoms.

Limitations

Current commercially available 3D print material does not have identical elastic, strength or biochemical properties to human valve tissue.
Use of an open circuit instead of a compliance chamber limits the ability to control diastolic pressures.
Further validation of 2D- and 4D flow-MRI is required in a larger number of phantom studies.
Fabricated valve leaflets had a 0.6 mm thickness, which is thicker than the more realistic 0.3 mm thickness.

Cite This Study

Hussein et al. (2020) studied Normal aortic valve function. 3D-printed aortic valve phantom and 4D Flow MRI was evaluated on Net flow proximal and distal to the valve. A 3D-printed aortic valve phantom demonstrated physiological function, with 4D Flow MRI showing consistent net flow proximal (26.03 mL/s) and distal (26.09 mL/s) to the valve.

synapsesocial.com/papers/6a153e76b03a896dfa81ff42 https://doi.org/10.1186/s41205-020-0057-8

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Simulation of semilunar valve function: computer-aided design, 3D printing and flow assessment with MR

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Simulation of semilunar valve function: computer-aided design, 3D printing and flow assessment with MR

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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