Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model
Key result
The fully-coupled fluid-structure interaction model with valves predicted a peak systolic velocity of 2.56 m/s, compared to 1.16 m/s in the model without valves and 2.17 m/s from Doppler echo data.
Why the study?
Does a fully-coupled FSI framework accurately predict valve dynamics and intraventricular hemodynamics compared to echocardiography and a valveless LV model?
Population
Realistic 3D left ventricle computational model incorporating native asymmetric leaflet geometries…
Comparison
Fully-coupled fluid-structure interaction… vs Subject-specific echocardiography data and a LV…
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May refine computational LV flow models; extends valveless approaches but leaves open human validation.
Key Points
- The aim is to examine the structural response of aortic and mitral valves and hemodynamics in a left ventricle model during the cardiac cycle.
- Developed a fully-coupled fluid-structure interaction framework combining smoothed particle hydrodynamics and nonlinear finite element method.
- Incorporated asymmetric leaflet geometries and hyperelastic material models using human material properties.
- Compared FSI simulation results with echocardiography data to validate the model.
- FSI model predicts peak systolic velocities of 2.56 m/s, compared to 1.16 m/s in a model without valves and Doppler echo data of 2.17 m/s.
- The model accurately predicted the opening and closing times of the valves and the large-scale intraventricular flow phenomena.
Structured PICO
Does a fully-coupled FSI framework accurately predict valve dynamics and intraventricular hemodynamics compared to echocardiography and a valveless LV model?
P
Population
Realistic 3D left ventricle (LV) computational model incorporating native asymmetric leaflet geometries, anisotropic hyperelastic material models, and human material properties
I
Intervention
Fully-coupled fluid-structure interaction (FSI) simulation combining smoothed particle hydrodynamics (SPH) and nonlinear finite element (FE) method
C
Comparator
Subject-specific echocardiography data and a LV model without valves
O
Outcome
Valve opening and closing times, mitral leaflet opening and closing angles, and large-scale intraventricular flow phenomena (including peak systolic velocities)surrogate
Main Result
Absolute Event Rate: 2.56% vs 1.16%
The proposed SPH-FE FSI framework accurately models patient-specific coupled LV-valve dynamics, showing better agreement with clinical echocardiography data than valveless models.
Limitations
- The mitral valve geometry was adapted from a previous study due to imaging artifacts in the subject-specific MSCT scans.
- Aortic valve calcification was not incorporated in order to mimic a healthy state.
- Absence of calcifications at the mitral annulus in the adapted model led to differences in diastolic parameters compared to clinical observations.
- Numerical artifacts caused spike values in stress and pressure measurements during valve closure and early systole.
Cite This Study
Mao et al. (2017) studied Normal left ventricular function (n=1). Fully-coupled fluid-structure interaction (FSI) simulation (LV-Valve model) vs. LV model without valves (LV-NoValve model) was evaluated on Peak systolic velocity (m/s). The fully-coupled fluid-structure interaction model with valves predicted a peak systolic velocity of 2.56 m/s, compared to 1.16 m/s in the model without valves and 2.17 m/s from Doppler echo data.