Key result
Lifestyle factors may boost nitric oxide bioavailability to potentially prevent or treat early SARS-CoV-2 infection.
Why the study?
Preexisting endothelial dysfunction and reduced nitric oxide bioavailability may drive severe COVID-19 complications, suggesting that restoring nitric oxide could offer a preventive or early-treatment strategy.
Do lifestyle factors that boost nitric oxide bioavailability prevent SARS-CoV-2 infection and COVID-19 progression?
Do lifestyle factors that boost nitric oxide bioavailability prevent SARS-CoV-2 infection and COVID-19 progression?
Lifestyle modifications that boost nitric oxide bioavailability, such as diet and exercise, represent a potential preventive or early-treatment strategy against COVID-19 and its thromboembolic complications.
Nitric oxide-boosting lifestyles may offer low-risk adjuncts in early SARS-CoV-2; leaves open efficacy pending randomized trials.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide and has seriously threatened public health by causing significant morbidity and mortality. Patients with coronavirus disease (COVID-19) with preexisting endothelial dysfunction caused by aging, diabetes, hypertension, and obesity are at high risk for life-threatening thromboembolic complications. This suggests a possibility that reduced endothelial nitric oxide (NO) production and NO bioavailability could be a common underlying pathology for the progression of COVID-19. Increasingly, evidence from experimental and clinical studies of SARS-CoV-2 infection shows that NO inhibits the pathogenesis of COVID-19, including virus entry into host cells, viral replication, host immune response, and subsequent thromboembolic complications. Restoring NO bioavailability may have the potential to be a preventive or early-treatment option for COVID-19. This review aims to provide in-depth discussion of NO bioavailability to prevent SARS-CoV-2 infection, particularly by focusing on lifestyle factors such as nitrate-rich diets, physical exercise, and nasal breathing, which could be easily performed on a daily basis to boost NO bioavailability.
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Jun Kobayashi (2021) conducted a review in COVID-19 / SARS-CoV-2 infection. Lifestyle factors (nitrate-rich diets, physical exercise, nasal breathing) was evaluated. Lifestyle factors including nitrate-rich diets, physical exercise, and nasal breathing may boost nitric oxide bioavailability to potentially prevent or treat early SARS-CoV-2 infection.
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