Key result
Focal PFA eliminates a complex inferoparaseptal accessory pathway with complete block and no 3-month recurrence.
Why the study?
Pulsed field ablation shows promise for complex accessory pathways in Wolff-Parkinson-White syndrome, but data on oblique courses are lacking.
Does focal pulsed field ablation safely and effectively eliminate an anatomically complex oblique inferoparaseptal accessory pathway?
Case Report (n=1)
No
Does focal pulsed field ablation safely and effectively eliminate an anatomically complex oblique inferoparaseptal accessory pathway?
Focal pulsed field ablation is a feasible and acutely effective approach for anatomically complex oblique inferoparaseptal accessory pathways, potentially avoiding the coronary injury risks associated with radiofrequency ablation.
Answers are grounded in this paper and cite their sources.
Case report supports focal PFA feasibility for complex inferoparaseptal pathways; leaves open comparative safety and durability versus RFA.
Background: Radiofrequency ablation (RFA) remains the gold standard for Wolff-Parkinson-White (WPW) syndrome with ∼94% acute success, ∼6% recurrence. Pulsed field ablation (PFA) shows promise for complex accessory pathways (APs) but lacks data on oblique courses. Case presentation: A 36-year-old endurance athlete presented with incidental right paraseptal pre-excitation before methylphenidate initiation. He reported self-terminating palpitations (∼200 bpm) during moderate cycling. Electrophysiological study revealed an oblique inferoparaseptal AP with right atrial insertion (inferior interatrial septum/CS roof, Kent potential) and left inferoparaseptal ventricular exit (earliest retrograde activation mid-CS 5/6). Due to right coronary artery proximity, focal PFA via Centauri™ system (Galvanize) achieved complete CS ostium/roof block. Post-procedure ventricular pacing showed retrograde decremental conduction. At 3 months, he reported no tachycardias/palpitations. Discussion/conclusion: This case demonstrates focal PFA's feasibility for an underrepresented oblique inferoparaseptal AP amid complex CS/CSMC anatomy, avoiding RFA's coronary injury risk. While early PFA series report >99% acute success, randomized long-term data vs. RFA are needed. PFA represents a promising investigational approach for anatomically challenging APs.
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Ebbinghaus et al. (2026) conducted a case report in Wolff-Parkinson-White syndrome with oblique inferoparaseptal accessory pathway (n=1). Focal pulsed field ablation (PFA) was evaluated on Complete conduction block and resolution of pre-excitation. Focal pulsed field ablation successfully eliminated an anatomically complex oblique inferoparaseptal accessory pathway, achieving complete conduction block with no recurrence at 3 months.
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