Key result
MRI assessment of myocardial fibrosis is crucial for diagnosing and predicting outcomes in HCM.
Why the study?
Myocardial fibrosis strongly correlates with the occurrence, development, and prognosis of HCM, prompting a review of its role in pathogenesis, diagnosis, and treatment.
Myocardial fibrosis, assessed via magnetic resonance imaging, is a key factor in the pathogenesis, diagnosis, and prognosis of hypertrophic cardiomyopathy.
Supports fibrosis imaging in HCM evaluation; leaves open prospective validation for risk algorithms.
Hypertrophic cardiomyopathy (HCM) is a type of hereditary cardiomyopathy caused by gene mutation. Its histological features include cardiomyocyte hypertrophy and disarray as well as myocardial fibrosis. Gene mutation, abnormal signal transduction, and abnormal energy metabolism are considered the main mechanisms of myocardial fibrosis. There is a strong correlation between myocardial fibrosis and the occurrence, development, and prognosis of HCM. We review the application of myocardial fibrosis in the diagnosis and treatment of HCM, focusing on research progress and the application of magnetic resonance imaging on the basis of the characteristics of fibrosis in the diagnosis and prognosis of HCM.
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Cheng et al. (2021) conducted a review in Hypertrophic cardiomyopathy. Myocardial fibrosis assessment, particularly using magnetic resonance imaging, is crucial for understanding the pathogenesis, diagnosis, and prognosis of hypertrophic cardiomyopathy.
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