Key result
Gene expression of TGF-beta1 and IGF-I was significantly elevated in ventricular biopsies from patients with idiopathic hypertrophic cardiomyopathy compared with non-HCM myocardium (P<0.01).
Observational (n=31)
p-value: p=<.01
Gene expression of TGF-beta1 and IGF-I is significantly enhanced in idiopathic hypertrophic cardiomyopathy, suggesting a potential role in its development.
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Supports TGF-β1/IGF-I involvement in idiopathic HCM; hypothesis-generating and should not yet change practice.
Li et al. (1997) conducted an observational in Idiopathic Hypertrophic Cardiomyopathy (n=31). Gene expression analysis of growth factors vs. Non-HCM myocardium (aortic stenosis, stable angina, ischemic cardiomyopathy) was evaluated on mRNA levels of TGF-beta1 and IGF-I (p=<.01). Gene expression of TGF-beta1 and IGF-I was significantly elevated in ventricular biopsies from patients with idiopathic hypertrophic cardiomyopathy compared with non-HCM myocardium (P<0.01).
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