Key result
Drug naïve depressed individuals had significantly higher baseline levels of TNF-α and IL-6 compared to healthy controls (P < 0.001 for both), with no significant differences between genders.
Why the study?
Are systemic inflammatory markers elevated in drug-naïve major depression compared to healthy controls?
Cross-Sectional (n=97)
No
Are systemic inflammatory markers elevated in drug-naïve major depression compared to healthy controls?
Absolute Event Rate: 63.3% vs 14.75%
p-value: p=<0.001
Drug-naïve major depression is associated with higher baseline levels of pro-inflammatory cytokines (TNF-α and IL-6), an association that is not mediated by gender.
Elevated TNF-α and IL-6 in drug-naïve depression; hypothesis-generating for causality and therapeutic targeting, pending prospective studies.
BACKGROUND: Evidence linking inflammation and depression is marred by several methodological inconsistencies. Further, varying information is present on the role of gender as a potential confounder in this association. AIMS: To assess systemic inflammation in drug naοve depression by measuring selected pro-inflammatory (tumor necrosis factor-alpha [TNF-α], interleukin-6 [IL-6]) and anti-inflammatory cytokines (transforming growth factor-beta [TGF-β]) and comparing them with a matched control group. We also aimed at exploring the differences in these markers between genders. SETTING AND DESIGN: The study was a cross-sectional one carried out a teaching cum Tertiary Care Hospital. MATERIALS AND METHODS: We recruited 55 drug naοve cases diagnosed with major depression and compared them for inflammatory markers with a matched apparently healthy control group (n = 42) at baseline. The inflammatory markers were also compared between the genders. Baseline depression and stress levels were assessed using standard measures. STATISTICAL ANALYSIS USED: Mann-Whitney U-test. RESULTS: In comparison with healthy controls, drug naοve depressed individuals demonstrated significantly raised baseline levels of TNF-α and IL-6 (P < 0.001 for both) but no difference in levels of TGF-β (P = 0.433). Neither the baseline depression nor the stress scores correlated with any of the inflammatory markers (P = 0.955 and 0.816 for TNF-α respectively). Males and females were comparable on the levels of markers studied (P = 0.986, 0.415, and 0.430 for TNF-α, IL-6 and TGF-β respectively). CONCLUSION: There is evidence for higher baseline inflammation in depression prior to starting anti-depressant therapy. Gender does not mediate this observed link between inflammation and depression.
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Muthuramalingam et al. (2016) conducted a cross-sectional in Major depression (n=97). Major depression vs. Healthy controls was evaluated on TNF-α level (p=<0.001). Drug naïve depressed individuals had significantly higher baseline levels of TNF-α and IL-6 compared to healthy controls (P < 0.001 for both), with no significant differences between genders.
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