Key result
Extracellular matrix components COMP and ADAMTS7 regulate vascular homeostasis and represent potential targets for atherosclerosis.
Why the study?
Alterations in vascular extracellular matrix components, interactions, and mechanical properties influence the formation and stability of atherosclerotic plaques, creating a need to explore the ECM microenvironment for novel therapeutic targets.
This review highlights the role of the ECM microenvironment, specifically COMP and ADAMTS7, as potential novel therapeutic targets for atherosclerosis.
May guide ECM-targeted atherosclerosis therapies; leaves open prospective clinical validation.
Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.
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Zhang et al. (2024) conducted a review in Atherosclerosis. ECM microenvironment targets (COMP and ADAMTS7) was evaluated. The extracellular matrix microenvironment, particularly components like COMP and ADAMTS7, plays a crucial role in vascular homeostasis and represents a potential therapeutic target for atherosclerosis.
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