Key result
Low levels of IgM antibodies against phosphorylcholine (<16.9 U/ml) were associated with an increased risk of incident myocardial infarction (adjusted RR 1.69; 95% CI 1.09-2.54).
Why the study?
Do low levels of IgM antibodies against phosphorylcholine predict the development of acute myocardial infarction?
Population
1,350 participants from a population-based cohort in northern Sweden, comprising 462 incident cases of first…
Comparison
Low levels of IgM antibodies against… vs Higher levels of anti-PC
Design
Case-control
Follow-up
13 years
Authors
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May identify higher-risk individuals but should not change practice; leaves open incremental predictive value over standard scores.
Case-Control (n=1,350)
Do low levels of IgM antibodies against phosphorylcholine predict the development of acute myocardial infarction?
Effect estimate: RR 1.69 (95% CI 1.09-2.54)
Low levels of natural IgM anti-PC are an independent risk marker for the development of myocardial infarction.
Grönlund et al. (2009) conducted a case-control in acute myocardial infarction (n=1,350). Low levels of IgM antibodies against phosphorylcholine (anti-PC) vs. Higher levels of anti-PC was evaluated on incidence of myocardial infarction (MI) (RR 1.69, 95% CI 1.09-2.54). Low levels of IgM antibodies against phosphorylcholine (<16.9 U/ml) were associated with an increased risk of incident myocardial infarction (adjusted RR 1.69; 95% CI 1.09-2.54).
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