Key result
Acute coronary syndromes are linked to ~2-fold higher procoagulant microparticles vs stable disease.
Why the study?
Elevated levels of procoagulant microparticles in peripheral blood of patients with recent plaque disruption and thrombosis were hypothesized but not established.
Are levels of procoagulant microparticles elevated in the peripheral blood of patients with acute coronary syndromes compared to those with stable angina or noncoronary heart disease?
Population
39 patients with coronary heart disease including 27 ACS, 12 stable angina, and 12 noncoronary heart disease patients
Comparison
Patients with ACS vs stable angina and noncoronary heart disease patients
Design
Observational study with microparticle isolation and prothrombinase assay
Authors
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May support endothelial microparticle role in ACS thrombosis; hypothesis-generating and should not yet change practice.
Observational (n=61)
Are levels of procoagulant microparticles elevated in the peripheral blood of patients with acute coronary syndromes compared to those with stable angina or noncoronary heart disease?
Absolute Event Rate: 22.2% vs 10.1%
p-value: p=<0.01
High levels of procoagulant endothelial microparticles are present in the circulating blood of patients with ACS, suggesting a potential role in the generation and perpetuation of intracoronary thrombi.
Mallat et al. (2000) conducted an observational in Acute coronary syndromes (n=61). Acute coronary syndromes vs. Stable angina or noncoronary heart disease was evaluated on Level of procoagulant microparticles (nmol/L phosphatidylserine equivalent) (p=<0.01). Acute coronary syndromes were associated with significantly elevated levels of procoagulant microparticles (22.2 nmol/L PS equivalent) compared with stable angina or noncoronary disease (P<0.01).
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