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November 9, 2021EP EuropaceOpen Access

Miniseries 1—Part I: the Development of the atrioventricular conduction axis

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Why the study?

Despite years of research, many details regarding the formation of the atrioventricular conduction axis remain uncertain.

Population

Human embryos and human foetal hearts between 10 and 30 weeks of gestation

Design

Observational embryological and histological study

Key result

The atrioventricular conduction axis originates from the primary interventricular ring, with the definitive node recognizable only after muscularization of the true second atrial septum.

Authors

JHJill P. J. M. HikspoorsYMYolanda MacíasJTJustin T. Tretter

Discussion

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Overview

Informs models of congenital conduction defects; leaves open clinical translation pending human validation.

Study Design

Type

Observational

Structured PICO

P
Population
Human embryos and serially sectioned human foetal hearts between 10 and 30 weeks of gestation
I
Intervention
Three-dimensional reconstructions of serial histological sections and episcopic datasets
O
Outcome
Developmental timeline and anatomical origins of the atrioventricular conduction axis

This study clarifies the developmental timeline and anatomical origins of the atrioventricular conduction axis in human embryos and foetuses.

Cite This Study

Hikspoors et al. (2021) conducted an observational in Embryonic heart development. The atrioventricular conduction axis originates from the primary interventricular ring, with the definitive node recognizable only after muscularization of the true second atrial septum.

synapsesocial.com/papers/6a154285b2e0231f15822dc1https://doi.org/10.1093/europace/euab287
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Revisiting the development of the atrioventricular conduction axis2026
  2. 2Developmental Origin, Growth, and Three-Dimensional Architecture of the Atrioventricular Conduction Axis of the Mouse Heart2010 · 143 citations
  3. 3The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis2018 · 30 citations
  4. 4Observations on the development of the human atrioventricular node and bundle1978 · 27 citations
  5. 5Development of the Myocardium of the Atrioventricular Canal and the Vestibular Spine in the Human Heart2001 · 102 citations