Key result
The atrial part of the atrioventricular conduction axis derives from the embryonic atrioventricular canal, whereas the atrioventricular bundle and lower nodal cells derive from ventricular myocardium.
Population
Postnatal mouse heart and embryonic models (Tbx2(+/Cre), Mef2c-AHF-Cre, Tbx18(+/Cre))
Design
Preclinical
Authors
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No immediate clinical implications; leaves open validation of dual AV axis origins in human hearts.
This study maps the 3D architecture and molecular signatures of the mouse atrioventricular conduction axis, revealing its dual developmental origins from both the embryonic atrioventricular canal and ventricular myocardium.
Aanhaanen et al. (2010) studied Atrioventricular conduction axis development. Genetic lineage labeling and 3D modeling was evaluated on Developmental origin of the specific components of the atrioventricular conduction axis. The atrial part of the atrioventricular conduction axis derives from the embryonic atrioventricular canal, whereas the atrioventricular bundle and lower nodal cells derive from ventricular myocardium.
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