The role of oxidized low-density lipoprotein in atherogenesis

Oxidized LDL have been shown to both stimulate and inhibit functions of vascular wall cells, contributing to all stages of the atherosclerotic reaction. It is becoming clear that the family of oxidation products in LDL, like the cytokine family, has many members with varying effects on different cell types. Identification of the products of oxidized LDL that contribute to the pathogenesis of atherosclerosis will have a considerable impact on future strategies for identification of indices of clinical assessment, for prevention, and for the treatment of coronary heart disease.