What is the clinical evidence from this study?

Study design: RCT. Population: Type 2 diabetes with risk of nephropathy (n=22). Intervention: Resistance training vs. Control group. Primary outcome: eGFR (mL/min) (ES 0.11, p=0.01).

What does this research mean for the field?

Eight weeks of resistance training prevents the deterioration of kidney function, maintaining eGFR levels, in type 2 diabetic patients at risk of nephropathy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 4, 2022Modern Care JournalOpen Access

Resistance Training Improved the Kidney Function of Type 2 Diabetic Patients with the Risk of Nephropathy: A Randomized Control Trial

View Full Paper

Ask AI

Bookmark

Key result

Eight weeks of resistance training prevents a ~17% decline in eGFR versus control.

ES 0.11
P=0.01
n=22

Why the study?

Despite the preventive role of resistance training in type 2 diabetes progression, its effects on diabetes-related kidney complications remain unknown.

Does an 8-week resistance training program improve kidney function and glycemic control in middle-aged men with type 2 diabetes at risk of nephropathy?

Comparison

Circuit resistance training vs control

Design

Randomized controlled trial

Follow-up

8 weeks

Authors

MMMehrzad MoghadasiIslamic Azad University Medical Branch of Tehran AOAlireza OstovarUniversity of Guilan AEAzita EslamiIslamic Azad University, Marvdasht

Discussion

Member takes

Implication

Supports resistance training in type 2 diabetes care to protect kidneys; extends glycemic benefits to renal preservation in RCT.

Study Design

Type

RCT (n=22)

Blinding

Single-blind

Randomization

Simple random sampling

Multicenter

Structured PICO

Does an 8-week resistance training program improve kidney function and glycemic control in middle-aged men with type 2 diabetes at risk of nephropathy?

Population

22 middle-aged men with established type 2 diabetes (fasting blood sugar ≥126 mg/dL and 2-hour post-prandial blood glucose ≥200 mg/dL) and CKD stages 2-4 (eGFR 20-90 mL/min/1.73 m2) for more than five years, having an inactive lifestyle, age 35 to 60 years (mean age 52.8), based in Iran.

Intervention

Circuit resistance training (RT) program consisting of 3 sessions per week, 60 minutes per session, 6 exercises, 3 sets, 8-15 repetitions at 50-80% of one-repetition maximum (1RM) for 8 consecutive weeks.

Comparator

Control group receiving no training intervention (asked not to change their diet until the end of the research).

Outcome

Changes in clinical parameters including insulin-like growth factor-binding protein 3 (IGFBP-3), estimated glomerular filtration rate (eGFR), fasting glucose, fasting insulin, and insulin resistance (HOMA-IR) before and after 8 weeks.surrogate

Main Result

Effect estimate: ES 0.11

Absolute Event Rate: 74.8% vs 74.5%

p-value: p=0.01

An 8-week resistance training program in men with type 2 diabetes prevented the decline of eGFR and improved glycemic control, suggesting a protective effect against the progression of diabetic nephropathy.

Limitations

Lack of strict diet control
Lack of blood pressure monitoring
Short training period
Small sample size
lack of strict diet control
lack of blood pressure monitoring
short training period
small sample size

Cite This Study

Moghadasi et al. (2022) conducted an RCT in Type 2 diabetes with risk of nephropathy (n=22). Resistance training vs. Control group was evaluated on eGFR (mL/min) (ES 0.11, p=0.01). Eight weeks of resistance training prevented the deterioration of kidney function, maintaining eGFR levels, while the control group experienced a significant 16.7% decrease in eGFR.

synapsesocial.com/papers/6a1545bfd64fa333899f75e5 https://doi.org/10.5812/modernc-128713

View Full Paper

Ask AI

Bookmark

Resistance Training Improved the Kidney Function of Type 2 Diabetic Patients with the Risk of Nephropathy: A Randomized Control Trial

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Resistance Training Improved the Kidney Function of Type 2 Diabetic Patients with the Risk of Nephropathy: A Randomized Control Trial

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider