Key result
Young adults (≤45 years) undergoing primary PCI for STEMI had significantly lower in-hospital mortality compared to older patients (46-74 years) (1.2% vs 5.4%, P<0.001).
Why the study?
Does primary PCI for STEMI have different mortality outcomes in young (≤45 years) compared to nonyoung (46-74 years) patients?
Cohort (n=2,424)
Does primary PCI for STEMI have different mortality outcomes in young (≤45 years) compared to nonyoung (46-74 years) patients?
Answers are grounded in this paper and cite their sources.
Young adults undergoing primary PCI for STEMI have significantly lower in-hospital and intermediate-term mortality and higher procedural success rates compared to older patients.
OBJECTIVES: We sought to determine in-hospital and intermediate-term outcomes of primary percutaneous coronary intervention (PCI) for ST elevation myocardial infarction (STEMI) in young adults. METHODS: We reviewed 2424 consecutive patients treated with primary angioplasty for acute MI; 465 were aged 45 or less (young group) and 1959 were 46-74 years of age (nonyoung group). Clinical characteristics, in-hospital and intermediate-term outcomes of primary PCI were analyzed. RESULTS: Compared with nonyoung patients, the young patients had significantly lower in-hospital and intermediate-term mortality (for in-hospital mortaliy: 5.4 vs. 1.2%, P<0.001; for intermediate-term mortality: 5 vs. 1.3%, P<0.001). By multivariate Cox regression analysis in all 2424 patients; cardiogenic shock, diabetes mellitus, anterior MI and unsuccessful procedure were independent predictors of both in-hospital and intermediate-term mortality whereas age [odds ratio (OR): 1.07, P<0.001], female sex (OR: 1.88, P = 0.04), MI history (OR: 3.05, P = 0.001) and multivessel disease (OR: 2.15, P = 0.01) were independent predictors of only intermediate-term mortality. The young group had lower unsuccessful procedure rates of primary PCI for STEMI (4.9 vs. 10.1%, P = 0.001). CONCLUSION: These results suggest that young adults who underwent primary PCI have favorable in-hospital and intermediate-term outcomes. Moreover, primary PCI for young adults with STEMI is safer, more feasible and effective than for a relatively older population.
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Ergelen et al. (2010) conducted a cohort in ST elevation myocardial infarction (n=2,424). Primary percutaneous coronary intervention in young adults (≤45 years) vs. Primary percutaneous coronary intervention in nonyoung adults (46-74 years) was evaluated on In-hospital mortality (p=<0.001). Young adults (≤45 years) undergoing primary PCI for STEMI had significantly lower in-hospital mortality compared to older patients (46-74 years) (1.2% vs 5.4%, P<0.001).
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