Atrial fibrillation in patients with ischemic stroke: A population-based study
Key result
Atrial fibrillation in first-time ischemic stroke patients was associated with an increased risk of one-year mortality (HR 1.55; 95% CI 1.30-1.85) and in-hospital medical complications.
Why the study?
Does the presence of atrial fibrillation worsen clinical outcomes in patients with first-time ischemic stroke?
Population
3,849 first-time ischemic stroke patients from the County of Aarhus, Denmark admitted in the period of…
Comparison
Presence of atrial fibrillation vs Absence of atrial fibrillation
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
May warrant closer monitoring in first-stroke AF patients; extends prior associations but leaves causal questions open for trials.
Study Design
Type
Cohort (n=3,849)
Structured PICO
Does the presence of atrial fibrillation worsen clinical outcomes in patients with first-time ischemic stroke?
P
Population
3,849 first-time ischemic stroke patients from the County of Aarhus, Denmark admitted in the period of 2003-2007
I
Intervention
Presence of atrial fibrillation
C
Comparator
Absence of atrial fibrillation
O
Outcome
30-day and one-year mortality, recurrent stroke, in-hospital medical complications, and length of stayhard clinical
Main Result
Effect estimate: HR 1.55 (95% CI 1.30-1.85)
Atrial fibrillation significantly increases the risk of mortality, medical complications, and recurrent stroke in patients with first-time ischemic stroke, especially those ineligible for oral anticoagulation.
Cite This Study
Thygesen et al. (2009) conducted a cohort in First-time ischemic stroke (n=3,849). Atrial fibrillation vs. No atrial fibrillation was evaluated on One year mortality (HR 1.55, 95% CI 1.30-1.85). Atrial fibrillation in first-time ischemic stroke patients was associated with an increased risk of one-year mortality (HR 1.55; 95% CI 1.30-1.85) and in-hospital medical complications.