Key result
In patients with cardioembolic TIA or stroke, the cumulative risk of recurrent cerebral embolism was 2.9% within three weeks, with underlying heart disease predicting recurrence.
Cohort (n=566)
In patients with cardioembolic stroke or TIA, underlying heart disease, age, prior stroke, and carotid disease are significant predictors of disabling or fatal outcomes, with a 2.9% risk of early recurrence.
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May inform early monitoring after cardioembolic events; leaves open optimal anticoagulation timing in prospective trials.
Functional outcome and recurrence rate were evaluated retrospectively in a series of 566 consecutive patients with a cardioembolic TIA or stroke. Seventy-five patients had a TIA/RIND, 163 a minor stroke, 238 a major deficit, and 90 a fatal event. In a logistic regression analysis the probability of a disabling or fatal outcome was significantly influenced by age (p = 0.0023), a previous stroke (p = 0.0262), concomitant carotid artery disease in Doppler sonography (p = 0.0210), and the underlying heart disease (p = 0.0001). Fatal or major strokes predominated among patients with nonvalvular atrial fibrillation, prosthetic heart valves, acute or chronic myocardial infarction. Kaplan-Meier estimates revealed a cumulative risk of recurrent cerebral embolism of 2.9% within three weeks. In a proportional hazards model only the underlying heart disease was significantly linked with the risk of recurrent embolism (p = 0.021).
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Hornig et al. (2009) conducted a cohort in cardioembolic TIA or stroke (n=566). In patients with cardioembolic TIA or stroke, the cumulative risk of recurrent cerebral embolism was 2.9% within three weeks, with underlying heart disease predicting recurrence.
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