Key result
Any minimal increase or profound decrease in serum creatinine within 48 hours after cardiothoracic surgery was associated with higher 30-day mortality compared to a slight decrease (2.1%).
Why the study?
Do minimal changes in serum creatinine within 48 hours postoperatively predict 30-day mortality in patients after cardiothoracic surgery?
Cohort (n=4,118)
Do minimal changes in serum creatinine within 48 hours postoperatively predict 30-day mortality in patients after cardiothoracic surgery?
Absolute Event Rate: 8.9% vs 2.6%
Even minimal increases or profound decreases in serum creatinine within 48 hours after cardiothoracic surgery are associated with substantially increased 30-day mortality.
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Alerts clinicians to monitor subtle creatinine changes after cardiothoracic surgery; extends observational data on renal markers but needs prospective confirmation.
Lassnigg et al. (2004) conducted a cohort in Postoperative cardiac and thoracic aortic surgery (n=4,118). Changes in serum creatinine within 48 h postoperatively vs. Slight decrease in serum creatinine was evaluated on 30-day mortality. Any minimal increase or profound decrease in serum creatinine within 48 hours after cardiothoracic surgery was associated with higher 30-day mortality compared to a slight decrease (2.1%).
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