Key result
Juvenile dermatomyositis links to reduced 3D global longitudinal and circumferential strain versus controls.
Why the study?
The study aimed to evaluate myocardial function and ascending aorta elasticity changes in juvenile dermatomyositis using three-dimensional strain analysis.
Does juvenile dermatomyositis affect myocardial function and aortic stiffness as measured by 3D echocardiography compared to healthy volunteers?
Case-Control (n=43)
Does juvenile dermatomyositis affect myocardial function and aortic stiffness as measured by 3D echocardiography compared to healthy volunteers?
Juvenile dermatomyositis is associated with subclinical reductions in myocardial strain and increased aortic stiffness, highlighting the potential utility of 3D echocardiography for early cardiovascular screening in this population.
Answers are grounded in this paper and cite their sources.
May indicate subclinical cardiac involvement in juvenile dermatomyositis; leaves open whether 3D strain screening improves outcomes.
OBJECTIVE: Our goal was to use three dimensional (3D) strain analysis to evaluate myocardial function and ascending aorta elasticity changes in juvenile dermatomyositis (JDM). METHODS: Between 2019 and 2021, 23 JDM patients and 20 healthy volunteers participated. Both groups underwent 2D and 3D strain analysis, assessing aortic stiffness using aortic distensibility, stiffness index, strain, and elastic modulus. RESULTS: JDM patients had a median age of 13.3 ± 5.2 years, while controls had a median age of 13.8 ± 4.76 years. 3D strain analysis revealed significantly lower global longitudinal (GLS) and circumferential strain (GCS) in JDM patients compared to controls. Specifically, 3D GLS was notably reduced in patients (-28.1% vs. -31%, p = .047) compared to controls, and 3D GCS was also lower in patients (-27.5% vs. -30.5%, p = .019) compared to controls. Aortic strain and elastic modulus were significantly lower in JDM patients, while aortic stiffness index and distensibility showed no significant differences. Correlation analyses within the JDM group revealed a negative correlation between 3D GLS and age at diagnosis (r = -.561, p = .04), as well as a positive correlation between 3D GLS and both aortic strain (r = .514, p = .0001) and elastic modulus (r = .320, p = .03) in JDM patients. CONCLUSION: Our study demonstrated a trend towards lower ejection fraction and strain in patients with JDM, along with increased aortic stiffness using 3D echocardiography. These findings suggest potential cardiovascular involvement in juvenile dermatomyositis, emphasizing the importance of comprehensive cardiac assessments in these patients.
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Dedeoğlu et al. (2024) conducted a case-control in Juvenile dermatomyositis (n=43). Juvenile dermatomyositis (disease exposure) vs. Healthy volunteers was evaluated on 3D global longitudinal strain (GLS) (p=0.047). Three-dimensional strain analysis demonstrated significantly reduced global longitudinal strain (-28.1% vs. -31.0%, p=0.047) and circumferential strain in juvenile dermatomyositis patients vs controls.
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