Role of oxidized low density lipoprotein in atherogenesis.

Abbreviations used in this paper: CAD, coronary artery disease; EDRF, endothelial-dependent relaxing factor; MDA-LDL, malodial- dehyde-conjugated LDL; Ox-LDL, oxidized LDL. per (Fig. In addition, LDL can be oxidized by incubation with crude soybean lipoxygenase (9). Several lines of evidence suggest that oxidation induced by endothelial cells (10) or by macrophages ( 11) depends on lipoperoxides generated intracel- lularly and then transferred to the LDL. Cellular lipoxygenases, especially 1 5-lipoxygenase, appear to be involved (10, 1 1). Al- ternatively, reactive oxygen species, such as superoxide anion, may be secreted into the medium, leading to initiation of lipid peroxidation in the LDL. This mechanism may predominate in smooth muscle cells (7). Once the LDL is "seeded" with Role ofOxidized Low Density Lipoprotein in Atherogenesis 1785