Key result
Higher baPWV correlates with lower bone mineral density, particularly in women.
Why the study?
The gender-specific association between brachial aortic pulse wave velocity and bone mineral density remains unclear.
Does the association between brachial aortic pulse wave velocity and bone mineral density differ between men and women?
Meta-Analysis (n=3,800)
Does the association between brachial aortic pulse wave velocity and bone mineral density differ between men and women?
Brachial aortic pulse wave velocity is negatively correlated with bone mineral density in women, highlighting the importance of considering gender-specific factors when assessing the relationship between cardiovascular and bone health.
Stronger negative correlation in women supports sex-specific assessment of arterial stiffness and bone health; extends meta-analytic evidence on gender differences.
BACKGROUND: Brachial aortic Pulse Wave Velocity (baPWV) and bone mineral density (BMD) are important indicators of cardiovascular health and bone strength, respectively. However, the gender-specific association between baPWV and BMD remains unclear. The aim of our study is to evaluate the relationship between baPWV and BMD in men and women populations METHODS: A comprehensive search was conducted in electronic databases for relevant studies published between the 1th and 30rd of April 2023. Studies reporting the correlation between baPWV and BMD in both males and females were considered. A random-effects model was used to calculate pooled correlation coefficients (r). RESULTS: Relevant data for both genders were found in six articles. In all publications included in the meta-analysis, the total number of studied individuals was 3800, with 2054 women and 1746 men. Pooled correlation coefficient was -0,24 (95 % CI: -0.34; -0.15) in women population, and -0.12 (95 %CI: -0.16, -0.06) in men. CONCLUSIONS: Based on the published data, we found that baPWV is negatively correlated with bone density in women. However, in men we do not find such a relationship. These findings suggest the importance of considering gender-specific factors when assessing the cardiovascular and bone health relationship.
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Jannasz et al. (2023) conducted a meta-analysis in Cardiovascular and bone health (n=3,800). Brachial aortic Pulse Wave Velocity (baPWV) vs. Gender (men vs women) was evaluated on Correlation between baPWV and bone mineral density (Pooled correlation coefficient (r), 95% CI -0.34 to -0.15 (women); -0.16 to -0.06 (men)). Brachial aortic pulse wave velocity was negatively correlated with bone mineral density in women (r=-0.24; 95% CI -0.34 to -0.15) and to a lesser extent in men (r=-0.12; 95% CI -0.16 to -0.06).
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