Key result
Intravenous administration of 17beta-estradiol increased aortic distensibility in postmenopausal women with and without coronary artery disease (P<0.01 and P<0.05, respectively).
Why the study?
Does intravenous 17beta-estradiol improve aortic elastic properties and reduce wave reflection in postmenopausal women with and without coronary artery disease?
Does intravenous 17beta-estradiol improve aortic elastic properties and reduce wave reflection in postmenopausal women with and without coronary artery disease?
p-value: p=<0.01 and <0.05
Intravenous 17beta-estradiol acutely improves aortic distensibility and reduces wave reflection in postmenopausal women, suggesting a beneficial physiological effect on the cardiovascular system.
Hypothesis-generating for acute vascular effects; leaves open whether estrogen therapy improves outcomes in postmenopausal women.
We hypothesized that estrogen may alter aortic elastic properties. The aortic pressure-diameter relation was obtained in 20 postmenopausal women, 10 without (group 1) and 10 with (group 2) proven coronary artery disease, before and after intravenous administration of 10 micrograms of 17beta-estradiol. Instantaneous aortic diameter was measured by an intravascular catheter developed in our institution simultaneously with aortic pressure at the same aortic level with a catheter-tipped micromanometer. At baseline, elastic properties of the aorta were decreased in group 2 compared with group 1. Compared with baseline, aortic distensibility was increased in both groups (P < 0.01 and P < 0.05 for groups 1 and 2, respectively) after estrogen administration, whereas the pressure-diameter loop was shifted downward along a different hypothetical line of elasticity, suggesting active changes in the aortic elastic properties. Furthermore, a significant reduction in wave reflection was found in both groups (P < 0.001). This action may contribute to the beneficial effects of estrogen on the cardiovascular system and may have future therapeutic implications in postmenopausal women.
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Stefanadis et al. (1999) studied Postmenopausal women with and without coronary artery disease (n=20). 17beta-estradiol vs. Baseline (before administration) was evaluated on Aortic distensibility (p=<0.01 and <0.05). Intravenous administration of 17beta-estradiol increased aortic distensibility in postmenopausal women with and without coronary artery disease (P<0.01 and P<0.05, respectively).
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