Key result
Acute radiofrequency ablation reduced action potential duration (by up to 41%) and conduction time in surrounding tissue, but these changes resolved within 22 ± 13 days.
Why the study?
Does radiofrequency ablation cause reversible electrophysiologic changes in the surrounding myocardium in isolated rabbit hearts?
Population
35 isolated perfused rabbit hearts
Comparison
Radiofrequency lesions produced on the… vs Baseline measurements prior to ablation
Design
Preclinical
Follow-up
22 +/- 13 days
Authors
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May explain post-ablation arrhythmia recurrences; hypothesis-generating in animal model and requires human validation.
Does radiofrequency ablation cause reversible electrophysiologic changes in the surrounding myocardium in isolated rabbit hearts?
Effect estimate: reduced by up to 41% and 19%
p-value: p=< 0.05
Radiofrequency ablation causes acute, reversible reductions in action potential duration and conduction time in surrounding myocardium, which resolve within approximately 3 weeks.
Wood et al. (2002) studied Electrophysiologic changes surrounding radiofrequency lesions (n=35). Radiofrequency (RF) ablation vs. Baseline was evaluated on Action potential duration at 50% repolarization (APD50) and 90% repolarization (APD90) within 2.5 mm from the lesion edge (reduced by up to 41% and 19%, p=< 0.05). Acute radiofrequency ablation reduced action potential duration (by up to 41%) and conduction time in surrounding tissue, but these changes resolved within 22 ± 13 days.
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