Key result
Antiseizure medication clearance drops by up to ~50% in elderly patients, requiring lower doses.
Why the study?
Epilepsy and ASM use are common in the elderly, where aging-related physio-pathological changes and polytherapy increase the risk of altered pharmacokinetics and drug-drug interactions.
How do age-related physiological changes affect the pharmacokinetics and dosing of antiseizure medications in the elderly?
Design
Literature review
Authors
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Warrants cautious ASM dosing in elderly; extends PK observations but leaves open randomized validation.
How do age-related physiological changes affect the pharmacokinetics and dosing of antiseizure medications in the elderly?
In elderly patients, antiseizure medication doses should generally be reduced and titrated slowly, with therapeutic drug monitoring to manage altered pharmacokinetics and polypharmacy risks.
Roberti et al. (2020) conducted a review in Epilepsy. Antiseizure medications was evaluated. Clearance of almost all antiseizure medications is reduced by about 20-50% in elderly patients compared with non-elderly adults, necessitating lower loading and maintenance doses.
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