April 1, 1994Journal of Applied Physiology
Lactic acidosis as a facilitator of oxyhemoglobin dissociation during exercise
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Implication
Randomized trial investigates lactic acidosis effects on oxyhemoglobin dissociation during exercise, suggesting significant physiological implications.
Key Points
- This study investigates how lactic acidosis influences the dissociation of oxyhemoglobin during exercise in healthy subjects.
- Examined femoral venous PO2, O2Hb saturation, pH, PCO2, lactate, and standard HCO3- during exercise tests.
- Two cycling protocols were employed: below and above the lactic acidosis threshold (LAT).
- Involved two groups of five healthy subjects to analyze the effects of increasing work rates.
- End-exercise O2Hb saturation decreased significantly above the LAT, with values of 13.8 +/- 4.2%.
- Most O2Hb dissociation during below-LAT exercise was due to decreasing capillary PO2.
- Acidification from lactic acidosis contributed to nearly all O2Hb dissociation above LAT.
Cite This Study
Stringer et al. (1994) studied this question.