Intensive blood pressure-lowering treatment decreased the risk for orthostatic hypotension compared to less intensive goals or placebo (OR 0.93; 95% CI 0.86 to 0.99).
Meta-Analysis (n=18,466)
Open-label
Effect estimate: OR 0.93 (95% CI 0.86 to 0.99)
Background: Although intensive blood pressure (BP)–lowering treatment reduces risk for cardiovascular disease, there are concerns that it might cause orthostatic hypotension (OH). Purpose: To examine the effects of intensive BP-lowering treatment on OH in hypertensive adults. Data Sources: MEDLINE, EMBASE, and Cochrane CENTRAL from inception through 7 October 2019, without language restrictions. Study Selection: Randomized trials of BP pharmacologic treatment (more intensive BP goal or active agent) that involved more than 500 adults with hypertension or elevated BP and that were 6 months or longer in duration. Trial comparisons were groups assigned to either less intensive BP goals or placebo, and the outcome was measured OH, defined as a decrease of 20 mm Hg or more in systolic BP or 10 mm Hg or more in diastolic BP after changing position from seated to standing. Data Extraction: 2 investigators independently abstracted articles and rated risk of bias. Data Synthesis: 5 trials examined BP treatment goals, and 4 examined active agents versus placebo. Trials examining BP treatment goals included 18 466 participants with 127 882 follow-up visits. Trials were open-label, with minimal heterogeneity of effects across trials. Intensive BP treatment lowered risk for OH (odds ratio, 0.93 95% CI, 0.86 to 0.99). Effects did not differ by prerandomization OH (P for interaction = 0.80). In sensitivity analyses that included 4 additional placebo-controlled trials, overall and subgroup findings were unchanged. Limitations: Assessments of OH were done while participants were seated (not supine) and did not include the first minute after standing. Data on falls and syncope were not available. Conclusion: Intensive BP-lowering treatment decreases risk for OH. Orthostatic hypotension, before or in the setting of more intensive BP treatment, should not be viewed as a reason to avoid or de-escalate treatment for hypertension. Primary Funding Source: National Heart, Lung, and Blood Institute, National Institutes of Health. (PROSPERO: CRD42020153753)
Juraschek et al. (Thu,) conducted a meta-analysis in Hypertension or elevated BP (n=18,466). Intensive BP-lowering treatment vs. Less intensive BP goals or placebo was evaluated on Orthostatic hypotension (decrease of ≥20 mm Hg systolic or ≥10 mm Hg diastolic BP after changing from seated to standing) (OR 0.93, 95% CI 0.86 to 0.99). Intensive blood pressure-lowering treatment decreased the risk for orthostatic hypotension compared to less intensive goals or placebo (OR 0.93; 95% CI 0.86 to 0.99).
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