Key result
Using multicellular fiber models, functional block occurred in tissue with a maximum APD gradient <45 ms/cm, and a steep conduction velocity restitution slope may help overcome cellular heterogeneity.
Computational modeling demonstrates that functional block depends on the spatial extent of action potential duration gradients and that steep conduction velocity restitution may protect against block from single premature beats.
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APD gradients <45 ms/cm permit functional block in models; hypothesis-generating for CV restitution and requires in vivo validation.
Sampson et al. (2001) studied Functional block and myocardial inhomogeneities. Premature stimuli in the presence of structural and ionic inhomogeneities was evaluated on Likelihood of premature stimuli to produce functional block. Using multicellular fiber models, functional block occurred in tissue with a maximum APD gradient <45 ms/cm, and a steep conduction velocity restitution slope may help overcome cellular heterogeneity.
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