Key result
Apixaban, edoxaban, fondaparinux, rivaroxaban, and darexaban prove most effective for preventing post-arthroplasty DVT.
Why the study?
The study was conducted to systematically review and compare the efficacy of 11 anticoagulants for preventing venous thromboembolism after total hip or knee arthroplasty.
Which of the 11 anticoagulants are most effective for preventing venous thromboembolism in patients undergoing total hip or knee arthroplasty?
Population
Patients undergoing total hip or knee arthroplasty across 61 included articles
Comparison
11 anticoagulants compared for prevention of VTE
Design
Systematic review and network meta-analysis
Authors
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These agents merit first-line use for post-arthroplasty VTE prophylaxis; strengthens network evidence among 11 anticoagulants.
Meta-Analysis
Which of the 11 anticoagulants are most effective for preventing venous thromboembolism in patients undergoing total hip or knee arthroplasty?
p-value: p=<.05
A network meta-analysis of 61 articles identifies apixaban, edoxaban, fondaparinux, rivaroxaban, and darexaban as the most effective anticoagulants for preventing deep vein thrombosis after total hip or knee arthroplasty.
Huang et al. (2023) conducted a meta-analysis in Venous thromboembolism after total hip or knee arthroplasty. 11 anticoagulants (including apixaban, edoxaban, fondaparinux, rivaroxaban, and darexaban) vs. Other anticoagulants was evaluated on Prevention of deep vein thrombosis (p=<.05). Apixaban, edoxaban, fondaparinux, rivaroxaban, and darexaban were the most effective anticoagulants for preventing deep vein thrombosis after total hip or knee arthroplasty (P < .05).
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