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March 1, 2000HypertensionOpen Access

Persons of equal weight who had higher initial blood pressures gain more weight in the future, hypothesized to be due to sympathetic overactivity and decreased beta-adrenergic responsiveness.

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Population

Persons with hypertension and overweight/obesity

Design

Review

Authors

SJStevo JuliusMVMariaconsuelo ValentiniPPPaolo Palatini

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Overview

Suggests hypertension may drive weight gain via sympathetic dysregulation; hypothesis-generating and challenges unidirectional causality, warranting prospective validation.

Structured PICO

P
Population
Persons with hypertension and overweight/obesity

This review proposes a pathophysiological hypothesis that hypertension-induced sympathetic overactivity downregulates beta-adrenergic receptors, reducing energy expenditure and promoting weight gain.

Cite This Study

Julius et al. (2000) studied this question.

synapsesocial.com/papers/6a1554f25347fbb1739f9bfehttps://doi.org/10.1161/01.hyp.35.3.807
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biochemical evidence of sympathetic hyperactivity in human hypertension.1991 · 99 citations
  2. 2Trials of Hypertension Prevention, phase II structure and content of the weight loss and dietary sodium reduction interventions1995 · 60 citations
  3. 3Sympathetics, insulin resistance and coronary risk in hypertension1994 · 127 citations
  4. 4Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension.1995 · 85 citations
  5. 5Body fat and sympathetic nerve activity in healthy subjects.1994 · 385 citations