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Warfarin monitoring using prothrombin time is problematic due to marked variability in the responsiveness of different thromboplastins to the anticoagulant effects of the drug.
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Highlights the variability in thromboplastin responsiveness and its impact on the interpretation of prothrombin time for warfarin monitoring.
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Jack Hirsh (1992) conducted an editorial in Warfarin therapy monitoring. Warfarin was evaluated. Warfarin monitoring using prothrombin time is problematic due to marked variability in the responsiveness of different thromboplastins to the anticoagulant effects of the drug.
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