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June 1, 1989Journal of Clinical InvestigationOpen Access

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.

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Authors

MAMorio AraiTokyo Metropolitan Institute of Medical ScienceDSDorothea ScandellaGoethe University FrankfurtLHLeon W. HoyerUniversity of Minnesota

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Arai et al. (1989) studied this question.

synapsesocial.com/papers/6a155b3b79ff98d0de4e7ff6https://doi.org/10.1172/jci114107
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin.1986 · 184 citations
  2. 2The interaction of bovine factor V and factor V-derived peptides with phospholipid vesicles.1983 · 172 citations
  3. 3Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues threonine351-serine365 of the factor VIII heavy chain.1988 · 76 citations
  4. 4FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting1987 · 14 citations
  5. 5Studies on the Nature of the Circulating Anticoagulant Directed against Antihemophilic Factor: With Notes on an Assay for Antihemophilic Factor1962 · 178 citations